Sentinel prevents heartworm, roundworms, and fleas in dogs. Some research has even shown that Sentinel is effective against mange mites. They advise it because it protects against a wide variety of diseases. As long as the dog or puppy is at least four weeks old and weighs more than two pounds, this parasite prophylactic may be used without worry. Side effects are possible with Sentinel, as they are with any pharmaceutical. Give the chewable pill to your pet just after it has eaten. Taking Sentinel for dogs with meals improves the absorption of one of its active components. Keep an eye out for any negative reactions during the following day or two.

Factors Contributing to Sentinel for Dogs’ Effectiveness

lufenuron and milbemycin oxime are both components of Sentinel. The active components are absorbed via the skin of the dog and retained in the dog’s adipose tissue. When a parasite consumes a host, it gains access to the host’s blood and a lethal dosage of the pharmaceuticals that eventually kill the parasite.

The use of lufenuron stops larvae from developing a hard shell. The fleas’ ability to develop into adults and reproduce depends on their exoskeleton.

Milbemycin triggers the opening of channels in the neurons of the parasite. The cells in the brain and spinal cord are negatively affected. In the end, this leads to cell death and paralysis, both of which are fatal.

What Are the Possible Risks of Using Sentinel on Dogs?

  • Hypersensitivity

Sentinel’s active ingredient, milbemycin oxime, has been linked to anaphylaxis in dogs with heartworm infection that had tested negative before starting therapy. Baby heartworms, known as microfilariae, release proteins into the circulation when they come into contact with the chemical and either die or become incapacitated. The product insert for Sentinel for Dogs warns that this might lead to many undesirable side effects, such as nausea, vomiting, excessive salivation, difficulty breathing, and lethargy.

  • Urticaria

Hives, or urticaria, are a common sign of an allergic response. They appear on the dog’s skin as red, itchy welts and might affect the whole body or just a small part of it. Sentinel has a small chance of causing hives, however this adverse effect never showed up during testing. Hives are only one symptom of an allergic response; be on the lookout for additional symptoms, such as your dog having difficulties breathing, swelling of the face, lips, or tongue, paw biting, weakness, and lethargy.

  • Diarrhea

During Sentinel for dogs clinical testing, just two out of 785 dogs had diarrhea. Because Sentinel is taken orally, it might react with the contents of the stomach, leading to nausea, vomiting, and diarrhea. In addition to potentially altering stomach pH, the medication may also lead to an uncomfortable gas buildup. If your dog has loose stools 24 to 48 hours after receiving Sentinel, it is important to provide him with lots of fresh, clean water and consult with your veterinarian.

When it comes to safeguarding your dog from potentially harmful insects like heartworms, fleas, and others, preventative treatment is essential. In order to provide the best care for your dog, it is important to discuss the potential advantages and dangers of commencing Sentinel for dogs with your pet’s veterinarian.

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Hey there! I'm Rodrigo, a passionate writer with a lifetime love for animals, especially dogs. Creating this blog is a dream come true for me so I hope you enjoy all our content!